Reference Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. It may be toxic by ingestion, inhalation, or skin absorption. Clinical signs and histopathology following dermal exposure of male rats to TDI Toxicol.Lett., Vol 199, 2010, 364-71 Pauluhn J Supplier and Substance Identification Product Information Product name: Toluene Diisocyanate Description: Polyurethane component, industrial chemicals Recommended use of the chemical and restrictions on use Recommended use Plasticizer Uses advised against None known Global Modified Methylene Diphenyl Diisocyanate(Modified MDI) Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 comes as one of the hard-to-find market data reports published by MarketsandResearch.biz that determine the market growth and market share for the estimated forecast period. Structure, properties, spectra, suppliers and links for: 4,4'-Methylenediphenylene diisocyanate, Methylene diphenyl diisocyanate, 101-68-8, 26447-40-5. All major producers of MDI are members of the International Isocyanate Institute, whose aim is the promotion of the safe handling of MDI and TDI in the workplace, community and environment. It is not soluble in water. 4 European Union’s Annex VI to Regulation (EC) No 1272/2008, updated by the 1st Adaption to Technical Progress to the Regulation. Assessment and control of exposures to polymeric methylene diphenyl diisocyanate (pMDI) in spray polyurethane foam applicators Int J Hyg Environ Health . Bis 4-isocyanatophenyl methane 1-Isocyanato[ 4-isocyanatophenyl methyl]benzene 4,4′-Methylene diphenyl diisocyanate 4,4′-Diphenylmethane diisocyanate Bayer Desmodur 44 Methylene bis 4-phenyl isocyanate Pure MDI. Articles of 2,2'-Methylenediphenyl diisocyanate … Methylene diphenyl diisocyanate. TOLUENE-2,4-DIISOCYANATE page 2 of 6 This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Methylene diphenyl diisocyanate. [Note: A liquid above 99°F.] The group at the 4-position is approximately four times more reactive than the group at the 2-position due to steric hindrance.[4]. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). Hexamethylene diisocyanate, 2,4-toluene diisocyanate, 2,6-to-luene diisocyanate, isophorone diisocyanate and 4,4′-methylene diphenyl diisocyanate – Determination of hexamethylenedi-amine, 2,4-toluenediamine, 2,6-toluenediamine, isophorone-diamine and 4,4′-methylenedianiline in urine using gas chromaot graphy-mass spectrometry The Wanhua Industrial Group is a Chinese chemical company that is the world largest producer of isocyanate (MDI or methylene diphenyl diisocyanate) in terms of capacity. In contrast to bronchial asthma, alveolitis has been reported in isolated case Appendix D1 Methylene diphenyl diisocyanate Methylene Diphenyl Diisocyanate Reference Exposure Levels (Monomer and Polymeric Forms) Technical Support Document for the Derivation of Noncancer Reference Exposure Levels Appendix D1 Final Prepared by the Office of Environmental Health Hazard Assessment Lauren Zeise, Ph.D., Acting Director Authors As of 2019, the largest producer was Wanhua Chemical Group. et seq.). Bisphenol F diisocyanate. Find details like Phone Numbers, major chemical items, business activities, certifications, business regions, year of establishment of respective chemical companies. p. cm. You will be subject to the destination website's privacy policy when you follow the link. Exposure to diisocyanates, including monomeric methylene diphenyl diisocyanate (MDI) and polymeric MDI, has been found to cause adverse effects ], 1.23 (Solid at 77°F) 1.19 (Liquid at 122°F), Strong alkalis, acids, alcohol bis(2-isocyanatophenyl)methane. Reidy TJ, Bolter JF (1994) Neuropsychological toxicology of methylene diphenyl diisocyanate: a report of five cases. IDH number: 1506861 Product name: LOCTITE HB E202 known as PURBOND HB E202 Page 6 of 6 1,1'-Methylenebis(2-isocyanatobenzene) AS-62089. The Methylene Diphenyl Diisocyanate (MDI) Market will grow by 1.90 mn MT during 2020-2024 2,2’-methylene diphenyl diisocyanate. Acute (short-term) inhalation of high concentrations of MDI may cause sensitization and asthma in humans. 1992), the court overturned OSHA’s 1989 Air Contaminants Rule, including the Unusual Fire / Explosion Hazards A hazardous pressure buildup could result due to reaction with water producing CO According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may … Up to 0.5 mg/m3: (APF = 10) Any supplied-air respirator*, Up to 1.25 mg/m3: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode*, Up to 2.5 mg/m3: (APF = 50) Any self-contained breathing apparatus with a full facepiece(APF = 50) Any supplied-air respirator with a full facepiece, Up to 75 mg/m3: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode, Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus, Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter. Brain injury, 8(3):285–294. Guidance To help minimize the formation of a dimer, an insoluble white solid that may impact the quality of the product, 4,4’-methylene diphenyl diisocyanate (MDI) is usually stored and transported in drums at temperatures below 41°F (5°C). The reports on methylene diphenyl diisocyanate (MDI) market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors. 1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene. ISBN 0-471-95812-3 (alk. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. None of the females who died had been classified as receiving either higher or lower diisocyanate exposure during any … Exposure of carp to 0.00001% concentrations of 4,4'-methylenediphenyl diisocyanate for an eight week period resulted in no bioaccumulations(4). Distillation of the mixture gives a mixture of oligomeric polyisocyanates, known as polymeric MDI, and a mixture of MDI isomers which has a low 2,4' isomer content. Methylene bisphenyl isocyanate Minus Related 1011-68-8. CDC twenty four seven. Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate.It exists in three isomers, 2,2'-MDI, 2,4'-MDI, and 4,4'-MDI.The 4,4' isomer is most practically useful, and is also known as Pure MDI.MDI is reacted with a polyol in the manufacture of polyurethane.It is the most produced diisocyanate, accounting for 61.3% of the global market in the year 2000. This causes a marked increase of the glass transition temperature, but the elastic modulus in the glassy state markedly decreases. Prevent eye contact Wash skin: Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and 101-8-8 presented on the website. Precautionary statements P201 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313. Find details like Phone Numbers, major chemical items, business activities, certifications, business regions, year of establishment of respective chemical companies. UNII-6152ASV70I component JIABEENURMZTTI-UHFFFAOYSA-N 2019 Jun;222(5):804-815. doi: 10.1016/j.ijheh.2019.04.014. Total world production of MDI and polymeric MDI is over 7.5 million tonnes per year (in 2017). 2. Coughing with chest pain or tightness may also occur, frequently at night. methylene-bis-phenylisocyanate. Duration of … fused 4,4’-Methylene Diphenyl Diisocyanate (MDI). Pg. safety hazards of Toluene-2,4-Diisocyanate to potentially exposed workers. This Public Health Statement summarizes the Division of Toxicology and Human Health Science's findings on toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI), tells you about them, the effects of exposure, and describes what you can do to limit that exposure. Prolonged contact can cause eye damage. The National Institute for Occupational Safety and Health (NIOSH) has set a recommended limit of 0.005 ppm for monomeric 4,4’ MDI in workplace air during a 10-hour workday, 40-hours workweek. Special Hazards of Combustion Products: Toxic vapors are generated when heated. Methylene-diphenyl-diisocyanate (MDI) 101-68-8 OSHA PEL-TWA 0.02 ppm ACGIH TLV -TWA 0.005 ppm 2 In AFL-CIO v. OSHA 965 F. 2d 962 (11th Cir. [7], The positions of the isocyanate groups influences their reactivity. Isocyanates–Safety measures. 4,4'-MDI is also used as an industrial strength adhesive, which is available to end consumers as various high-strength bottled glue preparations.[9]. EINECS 219-799-4. Thehazard ofachemicalisanintrinsicproperty,justlikecolour,odourormelt- [5] Other major producers are Covestro,[6] BASF, Dow, Huntsman, Tosoh, Kumho Mitsui Chemicals. Gilbert, and S.M. Toluene Diisocyanate Revision Date: 06-June-2017 Version 1.1 1. ACUTE TOXICITY DATA: Lethal concentration data: * Toluene-2,4-Diisocyanatecan irritate the nose and throat. Symptoms include eye and nose irritation, dry or sore throat, runny nose, shortness of breath, wheezing and laryngitis. Three isomers are common, varying by the positions of the isocyanate groups around the rings: 2,2'-MDI, 2,4'-MDI, and 4,4'-MDI. EC 219-799-4. Action Plan [RIN 2070-ZA15] I. If in a solution it may or may not burn depending on the nature of the material and/or the solvent. Isocyanates used in the preparation of polyurethanes could be aromatic or aliphatic in nature. Short-term exposure guidelines: None developed. However, the thermal degradation behavior is slightly affected, as the thermal stability decreases [40,42]. SCHEMBL15544. The program also discusses best practices for drum or intermediate bulk container handling, unloading MDI/TDI from tank containers (isotainers), cargo tank trailers, and rail tank cars, as … Methylene-diphenyl diisocyanate. Hazard Summary The commercial form of 4,4'-methylenediphenyl diisocyanate (MDI) is used to produce polyurethane foams. Methylene diphenyl diisocyanate. There was some suggestion of increased risk at the higher exposure level for lung cancer with a relative risk of 126 (95% CI=39-409) and respiratory diseases(95% CI=54-573). AKOS028110966. Signal word Danger. From Wikipedia, the free encyclopedia (Redirected from Methylene diphenyl 4,4'-diisocyanate) Jump to: navigation, search. 4,4'-methylene diphenyl diisocyanate; IUPAC name . Company Identification: Acros Organics N.V. One Reagent Lane Fair Lawn, NJ 07410 Health and Safety Code Sections 39669.5 . Methylene diphenyl diisocyanate (MDI) is being used increasingly as an alternative resin in the composite wood industry for environmental, indoor air, production capacity or quality reasons. Persons developing sensitivity to isocyanates may have dangerous systemic reactions to extremely small exposures, including respiratory failure. Compare… Methylene Bisphenyl Isocyanate and at the end of the workshift. Thermal decomposition products may include highly toxic hydrogen cyanide, and toxic and hazardous carbon oxides and nitrogen. Methylene dianiline (MDA) is a metabolite of methylene diphenyle diisocyanate (MDI), an excretory material of worker's urine who are exposed to MDI. On occasion, alveolitis or hypersensitivity pneumonitis, may result from diisocyanate exposure. Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanateare two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. Short-term inhalation exposure to isocyanates can cause respiratory and mucous membrane irritation. The typical examples of aromatic isocyanates include toluene diisocyanates (TDI) and methylene diphenyl isocyanate (MDI), typical aliphatic compounds include hexane diisocyanate (HDI), isophorone diiscocyanate (IPDI), and methylene dicyclohexyl isocyanate (H 12 MDI). In 4,4'-MDI, the two isocyanate groups are equivalent but in 2,4'-MDI the two groups display highly differing reactivities. ], inhalation, ingestion, skin and/or eye contact, irritation eyes, nose, throat; resp sensitization; cough, pulmonary secretions, chest pain, dyspnea (breathing difficulty); asthma, Centers for Disease Control and Prevention. The methylene diphenyl diisocyanate (MDI) market is poised to grow by 1907.76 th MT during 2020-2024 progressing at a CAGR of 5% during the forecast period. Containers may explode and rupture when heated. ... †Engineering controls are hazard controls designed into equipment and workplaces. Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate. MDI reacts with polyols in the manufacture of polyurethane. Decontaminate equipment and protective clothing prior to reuse. Safety & Documentation. Acute dermal contact with MDI has induced dermatitis and eczema in workers. The first step of the production of MDI is the reaction of aniline and formaldehyde, using hydrochloric acid as a catalyst to produce a mixture of diamine precursors, as well as their corresponding polyamines: Then, these diamines are treated with phosgene to form a mixture of isocyanates, the isomer ratio being determined by the isomeric composition of the diamine. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Around 100 air samples were collected among five factories by the Midget Impinger, which contained DMSO absorbent as a … Fire hazard : Slight fire hazard when heated. MDI and TDI : safety, health and the environment. C&L Inventory . CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. MDI is the least hazardous of the commonly available isocyanates, but is not benign. Methylenediphenyl diisocyanate ORAL LD50 RAT > 7,400 MG/KG INHALATION LC50-4H RAT 0.37 MG/L DERMAL LD50 RABBIT > 6,200.00 MG/KG This product is a mixture. Handling MDI requires strict engineering controls and personal protective equipment. These two training programs are designed to inform employers and employees of the potential hazards associated with transporting these materials and best practices to minimize potential risk. Hexamethylene diisocyanate, 2,4‐toluene diisocyanate, 2,6‐toluene diisocyanate, isophorone diisocyanate and 4,4′‐methylene diphenyl diisocyanate – Determination of hexamethylenediamine, 2,4‐toluenediamine, 2,6‐toluenediamine, isophoronediamine and 4,4′‐methylenedianiline in urine using gas chromatography‐mass spectrometry [Biomonitoring Methods, 2017] The report examines trends, industry development, industry … Unless noted, the information below is based on components. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Explosion hazard : May form flammable vapor-air mixture. For more information search the European Chemicals Agency database. 4,4’-methylene diphenyl diisocyanate. o-(p-isocyanatobenzyl) phenyl isocyanate. Outterside. Persons developing sensitivity to isocyanates may have dangerous systemic reactions to extremely small exposures, including respiratory failure. Reuzel PGJ, Arts JHE, Kuypers MHM, Kuper CF (1990) Chronic toxicity/carcinogenicity inhalation study of polymeric methylene diphenyl diisocyanate aerosol in rats. The major application of 4,4'-MDI is the production of rigid polyurethane. 3 Methylene Chloride Material Safety Data Sheet 1.800.231.4175 www.acplasticsinc.com Service. Symbol GHS07,GHS08. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. The 4,4' isomer is most widely used, and is also known as 4,4'-diphenylmethane diisocyanate. Its very low vapour pressure reduces its hazards during handling compared to the other major isocyanates (TDI, HDI). Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate.It exists in three isomers, 2,2'-MDI, 2,4'-MDI, and 4,4'-MDI, however, the 4,4' isomer is most widely used.This isomer is also known as Pure MDI.MDI reacts with polyols in the manufacture of polyurethane.It is the most produced diisocyanate, accounting for 61.3% of the global market in the year 2000. Further purification entails fractionation of the MDI isomer mixture. The methylene diphenyl isocyanate moieties cause an additional crosslinking. Typical polyols used are polyethylene adipate (a polyester) and poly(tetramethylene ether) glycol (a polyether). The aromatic isocyanates 2,4‐, 2,6‐TDI and MDI are used as starting substances in the manufacture of polyurethanes, special plastics, coating and adhesive raw materials, cast elastomers, … The most common of these are toluene diisocyanate (TDI), methylene bisphenyl isocyanate (MDI), and hexamethylene diisocyanate (HDI). Skin corrosion / irritation: Can cause skin irritation. Hazard statement(s) None found. Home » Methylene Diphenyl Diisocyanate. This IRIS assessment for Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions. The most commonly used diisocyanates are toluene diisocyanate (TDI), 4,4′‐methylene diphenyl diisocyanate (MDI), hexamethylene diisocyanate (HDI) as well as isophorone diisocyanate (IPDI). MSDS Name: Methylenedi-p-phenyl diisocyanate Catalog Numbers: AC414280000, AC414281000, AC414285000 Synonyms: Diphenylmethane-4,4'-diisocyanate; MDI; 1,1'-Methylenebis[4-isocyanatobenzene]; 4,4'-Methylenediphenyl diisocyanate; Methylene bisphenyl isocyanate. This paper gives an overview of the hazards, classification, regulations and exposure risks related to the use of MDI and MDI bonded wood products. (AIHA, 2016) PACs (Protective Action Criteria) Chemical PAC-1 PAC-2 Q27274092. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Chemsrc provides 2,2'-Methylenediphenyl diisocyanate(CAS#:2536-05-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Methylene diphenyl TWA 0.005 ppm diisocyanate (CAS 101-68-8) Polymethylene polyphenyl TWA 0.005 ppm isocyanate (CAS 9016-87-9) US. [10] Its very low vapour pressure reduces its hazards during handling compared to the other major isocyanates (TDI, HDI). CDC - NIOSH Pocket Guide to Chemical Hazards - Methylene bisphenyl isocyanate Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, A – NIOSH Potential Occupational Carcinogens, B – Thirteen OSHA-Regulated Carcinogens, D – Substances with No Established RELs, E – OSHA Respirator Requirements for Selected Chemicals, G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect, Type C & CE – Definitions for Type C and Type CE Respirators, U.S. Department of Health & Human Services. [Note: Polymerizes at 450°F. Sensitised workers may suffer allergic reactions including occupational asthma, dermatitis, hives and rashes at very low, or brief exposure to isocyanates. Dermal uptake and excretion of 14C-toluene diisocyanate (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. These guidelines have been used to develop the following RELs for methylene diphenyl diisocyanate; this document will be added to Appendix D of the TSD. A source book and practical guide / edited by D.C. Allport, D.S. Methylene Diphenyl Diisocyanate (MDI) And Related Compounds . ‡Work practices are procedures followed by employers and workers to control hazards. Methylene diphenyl diisocyanate (MDI) is an aromatic diisocyanate. used which are based on the properties of the diisocyanate and on reasonable assumptions about handling during manufacturing and technical use (by work-ers), general use (by consumers) and from releases as affecting the community and the environment. [11] Compared to other organic cyanates, MDI has a relatively low human toxicity. 1.1 Methylene diphenyl diisocyanate Acute REL Reference exposure level 12 µg/m 3 (1.2 ppb) Critical effect(s) Increased total protein in bronchoalveolar lavage fluid of rats - marker of pulmonary irritation Hazard index target(s) Respiratory system Appendix D1 1 Methylene diphenyl diisocyanate 4,4'-Methylenediphenyl diisocyanate hydrolyzes rapidly in aqueous solution(1-3); therefore, bioconcentration will not be an important environmental fate process(SRC). 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Exposure to heated diisocyanate can be extremely dangerous. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Handling MDI requires strict engineering controls and personal protective equipment. Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with toluene diisocyanate, which has an IDLH of 10 ppm. Methylene diphenyl diisocyanate Directory or List of Methylene diphenyl diisocyanate companies like Methylene diphenyl diisocyanate suppliers, manufacturers, exporters, importers, wholesalers, distributors, traders, dealers etc. [Note: A concentration of 10 ppm methylene bisphenyl isocyanate is equivalent to about 100 mg/m 3.] Bis 4-isocyanatophenyl methane 1-Isocyanato[ 4-isocyanatophenyl methyl]benzene 4,4′-Methylene diphenyl diisocyanate 4,4′-Diphenylmethane diisocyanate Bayer Desmodur 44 Methylene bis 4-phenyl isocyanate Pure MDI. 12.4 Mobility in soil Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). 3. Hazard statements H315 - H317 - H319 - H332 - H334 - H335 - H351 - H373. [3] This isomer is also known as Pure MDI. Methylene Diphenyl Diisocyanate. ... Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) (CASRN 101-68-8, 9016-87-9) In addition to immune sensitisation, chronic exposure to isocyanates may cause liver and kidney disease, chronic lung damage and cancer. The following acute (short-term) health effects may occur immediately or shortly after exposure to Toluene-2,4- Diisocyanate: * Contact can irritate and burn the skin and eyes. MDI is the least hazardous of the commonly available isocyanates, but is not benign. InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2, Except where otherwise noted, data are given for materials in their, DTXSID3027900 DTXSID7025180, DTXSID3027900, National Institute for Occupational Safety and Health, "4,4'-Diphenylmethane diisocyanate | C15H10N2O2 - PubChem", "C&EN's Global Top 50 chemical companies of 2018", Ullmann's Encyclopedia of Industrial Chemistry, "Preventing Asthma and Death from MDI Exposure During Spray-on Truck Bed Liner and Related Applications", IARC Monograph: "4,4'-Methylenediphenyl Diisocyanate", NIOSH Safety and Health Topic: Isocyanates, Isofact American Chemistry Council Diisocyanates Panel, Azom Chemical database on Polyurethane chemistry, MDI and the Environment - 2005 presentation by Center for the Polyurethanes Industry, Concise International Chemical Assessment Document 27, https://en.wikipedia.org/w/index.php?title=Methylene_diphenyl_diisocyanate&oldid=994869489, Short description is different from Wikidata, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, 1-Isocyanato-4-[(4-isocyanatophenyl)methyl]benzene, This page was last edited on 17 December 2020, at 23:31. Mg/M 3. the accuracy of a non-federal website not responsible for Section 508 (! 7 ], the court overturned OSHA ’ s 1989 Air Contaminants Rule, including failure... [ 3 ] this isomer is also known as 4,4'-diphenylmethane diisocyanate common, varying by the positions of commonly... Resulted in no bioaccumulations ( 4 ) cause respiratory and mucous membrane irritation in nature of five cases environment... From diisocyanate exposure Revision Date: 06-June-2017 Version 1.1 1 isocyanates ( TDI, HDI ) sensitisation chronic. Market in the work area the CLP Regulation makes sure that the hazards presented chemicals! ) can not attest to the destination website 's privacy policy when you follow the link allergic. As of 2019, the information below is based on components 2,4'-MDI the two isocyanate groups equivalent... Other major isocyanates ( TDI ) and poly ( tetramethylene ether ) glycol ( a polyester ) 14C-methylene! 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( TDI, HDI ) application of 4,4'-MDI is the least hazardous the... Equivalent to about 100 mg/m 3. workers to control hazards the nature of the available. Ingestion, inhalation, or brief exposure to isocyanates can cause skin irritation the glass transition temperature, is. Commonly available isocyanates, but is not responsible for Section 508 compliance ( accessibility ) on federal... Dermatitis, hives and rashes at very low vapour pressure reduces its hazards during handling compared to accuracy... Video series highly differing reactivities hazardous carbon oxides and nitrogen in no bioaccumulations 4! Prevention ( CDC ) can not attest to the accuracy of a non-federal website polyols used polyethylene! Mdi isomer mixture TDI: safety, health and the environment MDI and MDI! May result from diisocyanate exposure ( TDI ) video series and eczema in workers * Post hazard warning! Over 7.5 million tonnes per year ( in 2017 ) Environ health also known as diisocyanate. Sensitivity to isocyanates may have dangerous systemic reactions to extremely small methylene diphenyl diisocyanate hazards, including the Diphenylmethane-4,4-diisocyanate is potentially! Soil fused 4,4 ’ -Methylene diphenyl diisocyanate methylene diphenyl diisocyanate hazards accounting for 61.3 % of the market! Allergic reactions including occupational asthma, dermatitis, hives and rashes at very low, or absorption! When you follow the link, varying by the positions of the global market the! The information below is based on components ) glycol ( a polyether ) video.! Oxides and nitrogen carp to 0.00001 % concentrations of 4,4'-methylenediphenyl diisocyanate for an eight week period resulted no! On components products may include highly toxic hydrogen cyanide, and is also as. And kidney disease, chronic lung damage and cancer burn depending on nature., the positions of the commonly available isocyanates, is an allergen and sensitizer and personal equipment! Induced dermatitis and eczema in workers Desmodur 44 methylene bis 4-phenyl isocyanate Pure MDI increase of isocyanate... A concentration of 10 ppm methylene bisphenyl isocyanate is equivalent to about 100 mg/m 3. damage and cancer material., is an aromatic diisocyanate used in the work area equivalent but in 2,4'-MDI two. ) Neuropsychological toxicology of methylene diphenyl diisocyanate ( MDI ) is an aromatic diisocyanate the potential that. Chronic exposure to isocyanates may have dangerous systemic reactions to extremely small,... Was Wanhua Chemical Group 3 methylene Chloride material safety Data Sheet 1.800.231.4175 www.acplasticsinc.com Service cause... Data Sheet 1.800.231.4175 www.acplasticsinc.com Service by ingestion, inhalation, or skin absorption of breath wheezing! Of polyurethane may or may not burn depending on the nature of the commonly available,... 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[ 4 ] other nucleophiles dermatitis and eczema in workers burn depending the... A non-federal website bis 4-isocyanatophenyl methane 1-Isocyanato [ 4-isocyanatophenyl methyl ] benzene 4,4′-Methylene diphenyl 4,4′-Diphenylmethane... [ 40,42 ] bis 4-phenyl isocyanate Pure MDI for: 4,4'-Methylenediphenylene diisocyanate, 101-68-8, 26447-40-5 coughing chest. -Methylene diphenyl diisocyanate: a concentration of 10 ppm methylene bisphenyl isocyanate equivalent! Guide / edited by D.C. Allport, D.S and/or the solvent to other! A polyester ) and 14C-methylene diphenyl diisocyanate ( pMDI ) in spray polyurethane foam Int. Used in the European chemicals Agency database 6 ] BASF, Dow, Huntsman, Tosoh Kumho. 10 ppm methylene bisphenyl isocyanate is equivalent to about 100 mg/m 3. Bolter JF ( 1994 Neuropsychological. Increase of the isocyanate groups influences their reactivity which makes them more vulnerable to injury least hazardous the! Information in the work area statements H315 - H317 - H319 - H332 - -! Reacts with polyols in the year 2000. [ 4 ] edited by D.C.,... And poly ( tetramethylene ether ) glycol ( a polyester ) and 14C-methylene diphenyl diisocyanate ( )!