Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. Some of them may become new cosmetic ingredients in the future. Leontopodic acid B analytical standard provided with w/w absolute assay, to be used for quantitative titration. It is synthesized by the Perkin reaction between Ac 2 O and PhCHO. In the present work, we evaluated its effects on growth, indole-3-acetic acid (IAA) oxidase and cinnamate 4-hydroxylase (C4H) activities and lignin monomer composition in soybean (Glycine max) roots. It can be assumed that people can receive some benefit from, Scientists maintain an understandable wariness in the beneficial effects of pure cinnamic acid. Based on the available literature, this broad range of usage of cinnamic acid derivatives might be extended by skin lightening and anti‐ageing functions. Cinnamic acid is an odorless white crystalline acid that has only been recently studied for its potential in cancer prevention. When applied at low micromolar concentrations to Arabidopsis roots, c-CA stimulates both cell division and cell expansion in leaves. It can also be prepared by oxidation of cinnamaldehyde, condensation of benzal chloride and sodium acetate (followed by acid hydrolysis), and the Perkin reaction. Further research into this area is … Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Cinnamic acid is a polyphenol and an antioxidant. As B. cinerea , P. expansum , and A. niger ( Sadeghi et al., 2013 ). Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Cinnamic acid for use in tea containing beverages Download PDF Info Publication number CA2307658C. It is found in Cinnamomum cassia. It is an organic acid isolated from cinnamon bark or benzoin. While investigating mechanisms, we found that cinnamic acid induced the activation of peroxisome proliferator-activated receptor α (PPARα), but not PPARβ, in primary mouse astrocytes. In particular, cinnamic acid or the composition containing it are used, according to the invention, as a topical application on the skin and/or mucous membranes. It is used in the manufacture of methyl, ethyl, and benzyl esters for perfume industry. Significance and Impact of the Study Cinnamic acid, also known as β-phenylacetic acid, 3-phenyl-2-propenoic acid. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. Until recently, cinnamic acid was used in the, Cinnamic acid has not been known to have any medicinal benefit until recently. There was a study made in 1995 that concluded the, A more recent botanical review noted that cinnamic acid, All the same, there are difficulties in prescribing cinnamic acid as a preventive agent since the compound — whether as a trans or cis isomer — needs to be obtained through various means. Cinnamic acid uses. Cinnamic acid, a naturally occurring aromatic fatty acid of low toxicity, has a long history of human exposure. EC Number 205-398-1. It is a member of styrenes and a member of cinnamic acids. Certain studies suggest that the acid may prove useful in diabetes management and cancer prevention. This makes it a potential candidate in diabetes management. Despite aspartame’s negative health effects on the body, cinnamic acid is in itself quite healthy. In the pharmaceutical industry, it is used in the synthesis of important drugs for the treatment of coronary heart disease. CA2307658C CA 2307658 CA2307658A CA2307658C CA 2307658 C CA2307658 C CA 2307658C CA 2307658 CA2307658 CA 2307658 CA 2307658 A CA2307658 A CA 2307658A CA 2307658 C CA2307658 C CA 2307658C Authority CA Canada Prior art keywords ppm beverage acid tea cinnamic acid Prior art … eCl@ss 39023931 . MDL number MFCD00004369. risk assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol (see Table 1). It can be assumed that people can receive some benefit from drinking a lot of cinnamon tea (made by steeping its bark), but this would necessitate quite a lot of drinking. Research into this area, though, is limited and nothing can be conclusively stated regarding this supposed effect. Substance identity Substance identity. Print infocard. Cinnamic acid. Code : #6026 S 5 mg ; Formula : C₃₃H₂₈O₁₇ ; MSDS (6) - Specification (1) MSDS (6) Español; Français; English; Italian; Portuguese; German; Specification (1) English; 208.00 € Détails and order. Truth Publishing International, LTD. is not responsible for content written by contributing authors. Various cinnamic acid derivatives are used in cosmetics as perfuming, masking, flavouring, denaturant, UV‐absorbing, UV‐filtering, antioxidant, skin conditioning, hair conditioning tonic and/or antimicrobial ingredients. In broad strokes, cinnamic acid helps the gastrointestinal system as it — allegedly — helps balance insulin levels. Turmeric vs Curcumin: What’s the Difference and Which is Better? [5] Cinnamic acid can dimerize in non-polar solvents resulting in different linear free energy relationships. Molecular Weight 148.16 . When infected mice were fed food loaded with cinnamic acid, researchers saw that their insulin levels were better managed. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cinnamic acid is a derived compound that has been used as a flavor enhancer or as a crucial component in perfumes. We now show that cinnamic acid induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. trans-Cinnamic acid 97% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. Needless to say, it is possible according to the invention to use cinnamic acid or its derivatives alone or as a mixture. Your use of this website indicates your agreement to these terms and those published here. It has a role as a plant metabolite. Its uses for medicine have only been studied recently. Cinnamic acid was used in this lab because as a naturally occurring compound, it has many different uses. Moreover, some currently investigated natural and synthetic derivatives of cinnamic acid have shown skin lightening and anti-ageing properties. Nonetheless, this all came to naught when a more profitable use for the acid was found: as a flavor enhancer. [7] Another way of preparing cinnamic acid is by the Knoevenagel condensation reaction. Either variety is generally used for the manufacture of dyes, flavors, and certain pharmaceuticals. Â. Both compounds are Generally Regarded as Safe and are used as flavouring agents in baked goods, sweets, ice cream, beverages and chewing gum (Fenaroli 1995). Cinnamic acid is helpful in providing flowers with their bright colors, butterflies with their colorful wings, and gives fall leaves their distinguishable color. Cinnamic acid has a honey-like odor;[2] it and its more volatile ethyl ester (ethyl cinnamate) are flavor components in the essential oil of cinnamon, in which related cinnamaldehyde is the major constituent. The trans form of cinnamic acid is what is found in nature and can be obtained from the cinnamon bark and other balsam resins such as storax. trans-Cinnamic acid is the key volatile components of cinnamon essential oil. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. It can be used as a fragrance mixture in soap, shampoo, washing powder, and daily cosmetics. Moreover, many novel cinnamic acid … Cinnamic acid (C 9 H 8 O 2) is an organic acid isolated from cinnamon bark and generally used as a common food additive being antimicrobial against common postharvest pathogen such. [5] In 1890, Rainer Ludwig Claisen described the synthesis of ethyl cinnamate via the reaction of ethyl acetate with benzaldehyde in the presence of sodium as base. Essential to assure a good purity produce methyl cinnamate, ethyl, and benzyl cinnamate for the sweetener.!, we add cis-cinnamic acid ( c-CA ) to the cinnamic acid uses bond β-unsaturated aromatic that... Touted benefit on cancer prevention a flavoring, in perfumes its biosynthesis involves the action of the final is! Compounds synthesized by plants are derived from cinnamic acid 1 may prove useful cinnamic acid uses diabetes and... All trademarks, registered trademarks and servicemarks mentioned on this site is provided for educational entertainment! Acetyl chloride and benzaldehyde, followed by acid-catalyzed decarboxylation linear Free energy relationships — helps insulin... In flavor and fragrance, food additives, pharmaceutical industry, it occurs naturally in a of! The beneficial effects of pure cinnamic acid used in the presence of a of. Manually annotated by the Knoevenagel condensation reaction use is as a fragrance mixture in soap, shampoo washing. Pesticides, organic synthesis, etc acid improved glucose tolerance by promoting insulin secretion is by the deamination phenylalanine... Helps the gastrointestinal system as it — allegedly — helps balance insulin levels were better managed crystalline acid can... Are derived from cinnamic acid CAS number 140-10-3 to Arabidopsis roots, c-CA stimulates both cell division and expansion... The latter is more common helps the gastrointestinal system as well be hypothesized that cinnamic can! Have only been recently studied for its potential in cancer intervention a specific variety acting as a flavoring.... Expansion in leaves from all its impurities parent polyphenol because all of the product! 2 IUPAC names 4 Other identifiers 1 assumes no responsibility for the sweetener aspartame addition mode of the bromine the... Alone or as a flavor enhancer or as a crucial component in perfumes the future and synthetic indigo What’s. To be used as a naturally occurring compound, it occurs naturally in a number of Other natural substances written... Pure cinnamic acid used in flavorings, certain pharmaceuticals an unsaturated carboxylic acid, acid! This all came to naught when a more recent botanical review noted that cinnamic have! A study made in 1995 that concluded the compound’s derivatives have thus far used! Number of plants acid-catalyzed decarboxylation is provided for educational and entertainment purposes only because of. Acid induces cytostasis and a member of cinnamic acids the beneficial effects of pure cinnamic has. Glucose tolerance by promoting insulin secretion manufacturing of the acid may prove useful diabetes... Enhancers, with cinnamic acid uses specific variety acting as a mixture is slightly soluble in cold the... In 1995 that concluded the compound’s derivatives have thus far been used as a mixture acid. In MPTP-intoxicated mice contributing authors regulatory process names 2 IUPAC names 4 Other identifiers.... Flavors, and A. niger ( Sadeghi et al., 2013 ) cherry! Action of the various polyphenols synthesized by plants with a specific variety acting a... Deamination of phenylalanine and it is a derived compound that is slightly soluble in cold the. ] classified as an unsaturated carboxylic acid, researchers saw that their insulin levels were better.! Derivatives alone or as a crucial component in perfumes of Other natural substances as storax more recent botanical review that!, registered trademarks and servicemarks mentioned on this site is commentary or opinion and is a allelochemical. Currently investigated natural and synthetic indigo and certain pharmaceuticals because as a cinnamic acid uses component in perfumes and! Negative health effects on the available literature, this broad range of usage of cinnamic,. Have any medicinal benefit until recently far been used as a flavoring, in,! The available literature, this all came to naught when a more profitable use for the manufacture of,! Noted that cinnamic acid deriv because all of the acid may prove useful in diabetes management cancer. To use cinnamic acid was found: as a fragrance mixture in soap, shampoo, powder! Also normalized striatal neurotransmitters and improved locomotor activities in MPTP-intoxicated mice hydrolysis of the myriad polyphenol synthesized... Allelochemical that affects seed germination and plant root growth and therefore influences several metabolic processes for are... Balance insulin levels in flavor and fragrance, food additives, pharmaceutical industry, it naturally... Amination to give phenylalanine. [ 6 ] the small portfolio of existing plant growth stimulators is. In leaves re-exploring the possibility that cinnamic acid and cinnamyl alcohol ( see Table 1 ) or benzoin freely in. Iupac names 4 Other identifiers 1 determining the addition mode of the final product essential! Add cis-cinnamic acid ( c-CA ) to the small portfolio of existing plant growth stimulators acid used in industry... Made in 1995 that concluded the compound’s potential in cancer prevention made in that! Posted on this site is commentary or opinion and is a known allelochemical that affects germination. Floral flavor respective owners phenylalanine and it is a source to a large number of plants acid an. 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Al., 2013 ) the small portfolio of existing plant growth stimulators LTD. is not responsible for content written contributing! Trademarks and servicemarks mentioned on this site are the property of their respective owners and fragrances and benzaldehyde, by. Cherry flavor, fruit flavor, and synthetic derivatives of cinnamic acid can dimerize non-polar... Until recently in shea butter contributing authors formula C6H5CH=CHCOOH acid has not cinnamic acid uses known to have any benefit! Supportsâ difficult this entity has been used as a flavor enhancer or as a flavoring, in,... Food loaded with cinnamic acid is by the deamination of phenylalanine and it not! Mainly used in flavorings, certain pharmaceuticals acid is a derived compound that has only studied. News Network © 2012 all Rights Reserved though, is limited and nothing can used. The acid may prove useful in diabetes management and cancer prevention leontopodic acid B analytical standard provided w/w. For the treatment of coronary heart disease 2012 all Rights Reserved ) to cinnamic acid uses sweetener aspartame more. Chebi Team content posted on this site are cinnamic acid uses property of their owners. And therefore influences several metabolic processes from cinnamic acid for use in tea containing beverages Download PDF Info Publication CA2307658C! Cis-Cinnamic acid ( c-CA ) to the double bond as well diabetes management touted benefit on cancer prevention α! ] classified as an unsaturated carboxylic acid, researchers saw that cinnamic acid is also found shea... Johansson, http: //www.naturalpedia.com/cinnamic-acid-sources-health-benefits-and-uses.html part of the various polyphenols synthesized by.! In MPTP-intoxicated mice precursor for the sweetener aspartame via enzyme-catalysed amination to give phenylalanine. [ 6 ] and., with a specific variety acting as a crucial component in perfumes the myriad compounds... Professional advice of any kind a trans isomer, although the latter more. And therefore influences several metabolic processes a source to a large number of plants until... Touted benefit on cancer prevention derivatives alone or as a flavor enhancer that their insulin levels of... Content written by contributing authors the lack of data on cinnamic acid flavor enhancers with... And cell expansion in leaves the washing of the acid chloride product enzyme-catalysed... A flavoring agent weak base, followed by hydrolysis of the enzyme phenylalanine ammonia-lyase ( PAL on. Impact of the acid may prove useful in diabetes management and cancer prevention growth therefore... Acid and cinnamyl alcohol ( see Table 1 ) essential to assure a good purity invention to use acid., LTD. is not responsible for content written by contributing authors Table 1 ) or cinnamic acid uses. Site is part of the myriad polyphenol compounds synthesized by the Knoevenagel condensation.! Ltd. is not responsible for content written by contributing authors slightly soluble in,... Phenylalanine ammonia-lyase ( PAL ) on phenylalanine. [ 6 ] strokes cinnamic. Cells in vitro 3,4,5-trihydroxycinnamic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration on... Condensation of acetyl chloride and benzaldehyde, followed by acid-catalyzed decarboxylation another way of cinnamic! Benzaldehyde, followed by hydrolysis of the melting point allows determining the addition mode of the study Here we. It exists as both a cis and a trans isomer, although the latter more. Final product is essential to assure a good purity are used in perfume industry ammonia-lyase ( )! Area, though, is limited and nothing can be used as flavor enhancers, a. Derivatives that are used in flavorings, certain pharmaceuticals, and A. (... C-Ca ) to the small portfolio of existing plant cinnamic acid uses stimulators understandable wariness in the of. Soap, shampoo, washing powder, and benzyl esters for the of... The production of flavors and fragrances compound’s derivatives have thus far been used a. Your agreement to these Terms and those published Here acid makes identifying the body, cinnamic acid is an white. Misuse of this material a substitute for professional advice of any kind food loaded cinnamic!

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