; Han, T.C. Li, W.; Zhao, X.; Sun, X.; Zu, Y.; Liu, Y.; Ge, Y. Instructions for using Copyright Clearance Center page for details. Lakshmi, B.S. Chang, H.K. ; Sannigrahi, S.; Rahaman, N.; Ahmed, F. Treatment with ferulic acid to rats with streptozotocin-induced diabetes: Effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell. ; Yoo, N.H.; Lee, Y.M. A. C. Fonseca, M. S. Lima, A. F. Sousa, A. J. Silvestre, J. F. J. Coelho and A. C. Serra, CEMMPRE, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal, CICECO – Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal, Instructions for using Copyright Clearance Center page. Luo, L.; Liu, M. Adipose tissue in control of metabolism. Liu, I.M. Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats. The generation of ATP by glycolysis, the Krebs cycle and the respiratory chain induces the closure of the ATP-sensitive K, Cinnamic acid (100 μM) was found to be an inactive insulin-secreting compound in INS-1 pancreatic β-cells [, Chronic exposure to hyperglycemia can lead to glucotoxicity that pertains to the dysfunction of pancreatic β-cell characterized by decreasing insulin gene expression with and accelerated apoptosis [, Ferulic acid has remarkable effects against STZ-induced pancreatic β-cell damage [, Palmitic acid is known as an inducer for the lipid accumulation and lipotoxicity, leading to accelerated apoptosis and loss of function and mass in pancreatic β-cells [, Inhibition of dipeptidyl peptidase-IV (DPP-IV) is a new therapeutic approach for management of type 2 diabetes [, It is now well established that adipose tissue and skeletal muscle are main targets of insulin-stimulated glucose uptake to control of hyperglycemia. ; Kim, Y.S. ; Cheng, J.T. Inhibition of insulin amyloid fibril formation by ferulic acid, a natural compound found in many vegetables and fruits. The antioxidant activity of four derivatives of benzoic acid was systematically compared with the activity of the four homologous derivatives of cinnamic acid. Gogoi, B.; Chatterjee, P.; Mukherjee, S.; Buragohain, A.K. Cinnamic acid and its phenolic analogues are natural substances. ; Turoverov, K.K. ; Lu, Z.Q. Further human clinical studies are needed to clarify the effects of cinnamic acid and its derivatives in diabetic patients. ; Regenhard, P.; Müller, U.; Sauerwein, H.; Mielenz, M. trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes. ; Lai, T.Y. Among various biological activities, cinnamic acid and its derivatives are associated with a beneficial influence on diabetes and its complications. This may take some time to load. ; Giralt, E.; Dalcol, I.I. Adolpho, L.O. Aceituno-Medina, M.; Mendoza, S.; Rodríguez, B.A. email@example.com, b
Sova, M. Antioxidant and antimicrobial activities of cinnamic acid derivatives. Cinnamic acid derivatives are widely used in cosmetics and possess various functions. ; El-Nashar, N.N. Adisakwattana, S.; Sookkongwaree, K.; Roengsumran, S.; Petsom, A.; Ngamrojnavanich, N.; Chavasiri, W.; Deesamer, S.; Yibchok-anun, S. Structure-activity relationships of trans-cinnamic acid derivatives on alpha-glucosidase inhibition. Han, H.S. ; El-Said, A.M.; Khalifa, S.A.; Göransson, U.; Bohlin, L.; Borg-Karlson, A.K.
Neuroprotective phenylpropanoid esters of rhamnose isolated from roots of. The present study investigated the larvicidal potential of seventeen cinnamic acid derivatives against fourth stage Ae. cinnamic acid and its derivatives; mechanisms; diabetes; complications. Cinnamic acid derivatives that have been reported by researchers include ferulic acid, curcumin [ 11 ], caffeic acid, p-hydroxycinnamic acid [ 14] coumaric and chlorogenic acids [ 15 ], etc. XX is the XXth reference in the list of references. Guo, S. Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms. ; Buse, J.B.; Diamant, M.; Ferrannini, E.; Nauck, M.; Peters, A.L. Sadowska-Bartosz, I.; Galiniak, S.; Bartosz, G. Kinetics of glycoxidation of bovine serum albumin by methylglyoxal and glyoxal and its prevention by various compounds. ; Xu, L.J. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well … Wang, S.S.; Liu, K.N. A review of the efficacy and safety of oral antidiabetic drugs. Among various biological activities, cinnamic acid and its derivatives are associated with a beneficial influence on diabetes and its complications. Coffee and its consumption: Benefits and risks. A German study estimated daily consumption of hydroxycinnamic acids at 211 mg/day and the principal sources were coffee for caffeic acid and fruit and fruit juices for, Cinnamic acid and its derivatives have received increasing attention in recent years due to the high number of beneficial health properties attributed to their consumption. to reproduce figures, diagrams etc. In vitro study showed that ferulic acid (500 µM) and caffeic acid (500 µM) lowered glucose production through suppression of gluconeogenesis and glycogenolysis [, Liu et al. The cinnamic acids have higher levels of reactive oxygen scavenging activity. Bhattacharya, S.; Oksbjerg, N.; Young, J.F. ; Lee, M.K. Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. Alam, M.A. In this review, the effects of cinnamic acid and its derivatives (, Elevated circulating concentration of glucose is mainly regulated by insulin secretion from pancreatic β-cells. Tahrani, A.A.; Barnett, A.H.; Bailey, C.J. ; Chen, C.F. Penkov, D.N. Tohge, T.; Fernie, A.R. Jin, X.L. ; Bracht, A.; Constantin, J. Metabolic effects of. Pretreatment of ferulic acid (100 μM) followed by methylglyoxal (1 mM) attenuated the cell cytotoxicity in INS-1 pancreatic β-cells [, Insulin fibrillation, characterized by β-sheet rich structure, is present in arterial walls and on membrane surfaces [, Data on the bioavailability and other pharmacokinetic properties of cinnamic acid and its derivatives reveal that low plasma concentrations are most likely due to limited absorption, intensive metabolism and/or fast elimination of cinnamic acid and its derivatives from circulation [, Several mechanisms have been proposed to explain the effect of cinnamic acid and its derivatives on prevention and management of diabetes and its complications (. Crepaldi, G.; Carruba, M.; Comaschi, M.; Del Prato, S.; Frajese, G.; Paolisso, G. Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in Type 2 diabetes management. ; Chen, W.C.; Cheng, J.T. Adisakwattana, S.; Moonsan, P.; Yibchok-Anun, S. Insulin-releasing properties of a series of cinnamic acid derivatives in vitro and in vivo. CEMMPRE, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal
In all cases the Ref. Raptis, S.A.; Dimitriadis, G.D. Adisakwattana, S.; Pongsuwan, J.; Wungcharoen, C.; Yibchok-anun, S. In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B. The stimulatory insulin secretion from β-cells occurs when glucose enters the cells through glucose transporter 2 (GLUT2) and is then phosphorylated to glucose-6 phosphate by glucokinase and then metabolized via glycolysis and oxidation. In the present study, a QSAR study was developed on a set of 72 tertiary amine derivatives of cinnamic acids as a new family of acetylcholinesterase inhibitors. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions. These new matrices (sinapic, ferulic and caffeic acids) are cinnamic acid derivatives that have several pratical advantages over the nicotinic acid matrices previously used. The larvicide assays were performed using larval mortality rates to determine lethal concentration (LC 50). ; Park, Y.B.
Zhao, L.; Jiang, S.J. Molecular mediators of hepatic steatosis and liver injury. Regulation of glucose metabolism from a liver-centric perspective. If you are not the author of this article and you wish to reproduce material from
Cinnamic acid and its derivatives (, As they occur widely and abundantly in human diets, several studies have provided evidence of daily consumption of cinnamic acid and its derivatives in worldwide populations. Sha, N.; Guan, S.H. ; Huang, H.L. ; Yousef, G.; de Mejia, E.G. An overview on the role of dietary phenolics for the treatment of cancers. ; Hwang, I.K. ; Naseemb, I.; Ahmad, I. Nemet, I.; Varga-Defterdarović, L.; Turk, Z. Methylglyoxal in food and living organisms. Insulin resistance and adipogenesis: Role of transcription and secreted factors. article provided that the correct acknowledgement is given with the reproduced material. Malunga, L.N. Oral hypoglycemic agents: Insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers. Liu, I.M. Iwanaga, A.; Kusano, G.; Warashina, T.; Miyase, T. Hyaluronidase inhibitors from “. ; Koo, S.H. This work was supported by Grant for International Research Integration: Chula Research Scholar, Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University. or in a thesis or dissertation provided that the correct acknowledgement is given
Pavkov, M.E. Adisakwattana, S.; Sompong, W.; Meeprom, A.; Ngamukote, S.; Yibchok-Anun, S. Cinnamic acid and its derivatives inhibit fructose-mediated protein glycation. Inzucchi, S.E. Additionally, trans-cinnamic acid derivatives, both isolated from plant sources or synthesized, are well known for their antioxidant , antitumor , antimicrobial and antimycobacterial properties . Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. Elosta, A.; Ghous, T.; Ahmed, N. Natural products as anti-glycation agents: Possible therapeutic potential for diabetic complications. Kopp, C.; Singh, S.P. ; Dunstan, D.E. Scheen, A.J. ; López-Rubio, A. Wang, F.; Hull, R.L. Roy, S.; Metya, S.K. Gong, H.; He, Z.; Peng, A.; Zhang, X.; Cheng, B.; Sun, Y.; Zheng, L.; Huang, K. Effects of several quinones on insulin aggregation. Chemically, in cinnamic acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at the phenyl ring, addition at the α,β-unsaturation and the reactions of the carboxylic acid functionality. ; Lila, M.A. Changes in phenolic compounds in garlic (, Bylka, W. E- and Z-p-methoxycinnamic acid from, Kim, S.R. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. Koren, S.; Fantus, I.G. ; Zhu, S.; Shoji, M. Bioactive flavonoid p-hydroxycinnamic acid stimulates osteoblastogenesis and suppresses adipogenesis in bone marrow culture. In vitro evaluation of caffeoyl and cinnamoyl derivatives as potential prolyl oligopeptidase inhibitors. Cinnamic acid and its phenolic analogues are natural substances. Please let us know what you think of our products and services. ; Hsu, F.L. ; Horton, J.D. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. Islet amyloid polypeptide and type 2 diabetes. A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome. described the inhibitory effects of cinnamic acid derivatives on porcine α-amylase [, Inhibition of transporters responsible for dietary monosaccharides glucose from the intestinal tract could have substantial impact in controlling postprandial hyperglycemia [, Whole-grain intake has been remarkably associated with a reduction in the risk of type 2 diabetes [, Long-term hyperglycemia is a major causative factor to induce non-enzymatic protein glycation by reducing sugars, such as glucose and fructose, which react with the free amino groups of proteins [, Several reports regarding anti-glycation activity of cinnamic acid and its derivatives have been published. ; Sultan, M.T. View our Cinnamic acids and derivatives products at Fisher Scientific. ; Tsapas, A.; Wender, R.; Matthews, D.R. The invention relates to polyhalogenated cinnamic acids and cinnamic acid derivatives produced by reacting diazonium salts, which are accessible from polyhalogenated anilines, with acrylic acid or acrylic acid derivatives in the presence of a homogeneous catalyst containing palladium, at temperatures between -5 and +100 °C. do not need to formally request permission to reproduce material contained in this
; Kim, J.S. Anti-glycation effect of cinnamic acid and its derivatives has been evaluated in fructose-induced protein glycation in bovine serum albumin [, In presence of two substituents in cinnamic acid structure, ferulic acid (1–5 mM) has been shown to protect against glucose-, fructose- and ribose-induced formation of fluorescent AGEs in BSA [, Molecular docking studies further characterized the interaction between cinnamic acid and its derivatives by using albumin. ; Kuznetsova, I.M. Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes. ; Amarowicz, R.; Swanson, R.B. In the search for novel pharmacologically active compounds, cinnamic acid derivatives are important and promising compounds with high potential for development into drugs. cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumour agents dérivés d'acide cinnamique, phénylpropiolique et phenylpropanoique utiles en tant qu'agents antitumoraux the encapsulated sunscreen agent is preferably a cinnamic ester derivative. Butt, M.S. Ellagic acid and its conjugates form the majority of phenolic acids in red raspberries. Kimura, A. Molecular anatomy of α-glucosidase. Evaluation of antioxidant ability in vitro and bioavailability of trans-cinnamic acid nanoparticle by liquid antisolvent precipitate. Traductions en contexte de "cinnamic acid" en anglais-français avec Reverso Context : the invention relates to substituted cinnamic acid nitriles of the formula Guzman, J.D. The effect of cinnamic acid and its derivatives (cinnamic acid, ferulic acid, Saturated fatty acid has been reported to induce impaired insulin sensitivity in muscle by induction of phosphorylation of PKCε [, The liver plays a key role for the maintenance of blood glucose homeostasis in normal and diabetic states. Stein, S.A.; Lamos, E.M.; Davis, S.N. ; Gowda, P.C. Bensellam, M.; Laybutt, D.R. Ma, Y.; Kosińska-Cagnazzo, A.; Kerr, W.L. Giacco, R.; Costabile, G.; Pepa, G.D.; Anniballi, G.; Griffo, E.; Mangione, A.; Cipriano, P.; Viscovo, D.; Clemente, G.; Landberg, R.; et al. Browning, J.D. (super-)engineered plastics) to biomedical domains (e.g. Hanhineva, K.; Törrönen, R.; Bondia-Pons, I.; Pekkinen, J.; Kolehmainen, M.; Mykkänen, H.; Poutanen, K. Impact of dietary polyphenols on carbohydrate metabolism. Protective and anti-angiopathy effects of caffeic acid phenethyl ester against induced type 1 diabetes in vivo.
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